Journal of Stroke

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Review

September 29, 2025

Glucagon-Like Peptide-1 Receptor Agonists in the Prevention of Ischemic Stroke: Therapeutic Potential and Mechanisms

Zhenzong Lin, Zixiao Li, Qian Jia

J Stroke. 2025;27(3):289-301.

Numerous randomized controlled trials have demonstrated that glucagon-like peptide-1 receptor agonists (GLP-1RAs) can reduce the risk of stroke across various populations, likely because of their effectiveness in lowering the incidence...

Review

September 17, 2025

Time to Consider Pharmacologic Management of Unruptured Intracranial Aneurysms?

Yeon Soo Kim, Sungbin Hwang, Mi Hyeon Kim, Boseong Kwon, Yunsun Song, Deok Hee Lee

J Stroke. 2025;27(3):302-312.

The increasing detection rate of unruptured intracranial aneurysms (UIAs) using advanced imaging underscores the need for alternative management strategies beyond surgical and endovascular interventions. Although these procedures have improved substantially,...

Review

September 29, 2025

Stem Cell–Derived Extracellular Vesicle Therapy in Ischemic Brain Injuries

Chunfang Qiu, Abel Lindley, Xiaofeng Jia

J Stroke. 2025;27(3):313-328.

Ischemic brain injury (IBI), including stroke and cardiac arrest-induced global cerebral injury, presents a significant clinical challenge due to its high morbidity and incidence of neurological deficits. Currently, effective strategies...

Review

September 29, 2025

Asian-Pacific Expert Opinion on Patent Foramen Ovale Closure: Review of New Evidence and Focused Update

Jong S. Kim, Hans Cristoph Diener, Ting-Ting Low, Bert Albers, Vijay Kumar Sharma, Bum Joon Kim

J Stroke. 2025;27(3):329-337.

In 2020, clinical experts from leading Asian-Pacific cardiology and neurology centers published an expert opinion and consensus statement on transcatheter patent foramen ovale (PFO) closure for patients in the Asian-Pacific...

Review

September 29, 2025

Decision-Making for Endovascular Thrombectomy in Patients With Large Vessel Occlusions and Mild Neurological Deficit: A Consensus Statement

Salome L. Bosshart, Manon Kappelhof, Alexander Stebner, Satoru Fujiwara, Petra Cimflova, Marie-Sophie Schüngel, Genevieve Milot, Pascal J. Mosimann, Joanna D. Schaafsma, Marc Ribo, et al.

J Stroke. 2025;27(3):338-349.

Acute ischemic stroke patients with mild deficits (National Institutes of Health Stroke Scale [NIHSS] of 0–5) but confirmed large vessel occlusions (LVO) present a clinical challenge for endovascular thrombectomy (EVT)...

Original Article

September 29, 2025

Atrial Cardiopathy Worsens Neurological Severity, Raises Recurrence Rates, and Leads to Poor Vascular Outcomes in Patients With Embolic Stroke of Undetermined Source

Sung Hun Kim, Hyung Jun Kim, Hyun Kyung Kim, Jang-Hyun Baek, Hahn Young Kim, Yang-Ha Hwang, Sung Hyuk Heo, Ho Geol Woo, Hyungjong Park, Sung-Il Sohn, et al.

J Stroke. 2025;27(3):350-359.

Background and Purpose Atrial cardiopathy (AC) has been studied for its significance in embolic stroke of undetermined source (ESUS). This real-world study examines the relevance of AC in ESUS and...

Original Article

September 17, 2025

Varying Rates of Hospital Reperfusion Therapy for Stroke: Insights From Analysis of National Stroke Audit Data

Jong-Moo Park, Hong-Kyun Park, Seong-Eun Kim, Yong-Jin Cho, Jun Yup Kim, Beom Joon Kim, Kwang-Yeol Park, Kyung Bok Lee, Soo Joo Lee, Hyunji Oh, et al.

J Stroke. 2025;27(3):360-369.

Background and Purpose Disparities in stroke care exist globally. While reperfusion therapy is a standard treatment for acute ischemic stroke, variations in its implementation may exist across hospitals. Methods We analyzed...

Original Article

September 29, 2025

Previous Antiplatelet Therapy on Ticagrelor-Aspirin and Clopidogrel-Aspirin Efficacy in Intracranial Artery Stenosis

Qin Xu, Zongzheng Lyu, Yijun Zhang, Xue Xia, Xue Tian, Xiaoli Zhang, Yongjun Wang, Xia Meng, Anxin Wang

J Stroke. 2025;27(3):370-380.

Background and Purpose This study aims to investigate the effects of previous antiplatelet therapy on the efficacy and safety of ticagrelor-aspirin versus clopidogrel-aspirin among patients with and without intracranial artery...

Original Article

September 29, 2025

LIGHT/TNFSF14 Levels in Carotid Plaques Are Associated With Symptomatic Cerebrovascular Disease

Isabel Gonçalves, Jiangming Sun, Pratibha Singh, Mengyu Pan, Chrysostomi Gialeli, Eva Bengtsson, Jan Nilsson, Esther Lutgens, Andreas Edsfeldt, Annelie Shami

J Stroke. 2025;27(3):381-389.

Background and Purpose Plaque rupture is the underlying cause of most cardiovascular events, such as stroke and myocardial infarction. The co-stimulatory molecule LIGHT (tumor necrosis factor superfamily member 14, TNFSF14)...

Original Article

September 29, 2025

Moving From CT-First to MRI-First Paradigm in Acute Ischemic Stroke: Treatment Rates, Time Metrics, Safety, and Outcomes

Costanza Maria Rapillo, Vincent Dunet, Alexander Salerno, Silvia Pistocchi, Vincent Darioli, Bruno Bartolini, Francesco Puccinelli, Steven David Hajdu, Guillaume Saliou, Patrik Michel, et al.

J Stroke. 2025;27(3):390-401.

Background and Purpose Neuroimaging is essential before intravenous thrombolysis (IVT) and endovascular treatment (EVT) for acute ischemic stroke (AIS). In May 2018, our center transitioned from computed tomography (CT) to...

Current Issue: Volume 27(3); Sep 2025

Patient-Specific Hemodynamic Simulation for Predicting Stroke Laterality in Cardiac Embolism

Mahbod Issaiy, Diana Zarei, David S. Liebeskind, Pouria Moshayedi

[Epub ahead of print]

Original Article

September 17, 2025

Journal Impact Factor 8.6

	Editorial Office Department of Neurology, Asan Medical Center,Ulsan University College of Medicine 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Submission, status and progress, etc ⟫ E-mail: editor@j-stroke.org Website and system ⟫ E-mail: journal@m2community.co.kr Publishing company ⟫ E-mail: ka72sus@smileml.com
	Copyright © 2025 by Korean Stroke Society.